Manolis Angelakas studied Pharmacy and Chemistry at the University of Athens. He started his career in 1985 working in pharmaceutical industries and in 1990 he founded his own pharmaceutical company.
He has been Secretary and President of the Hellenic Association of Pharmacists. He has participated as a lecturer in many international scientific conferences and he has published scientific papers in pharmaceutical journals. He is a member of international Pharmaceutical Scientific Associations.
As a student in University he got involved with politics, serving as President of the political party of New Democracy at Athens School of Pharmacy throughout the years of his studies. From 1984 to 1997 he served as General Secretary and President of the Local Union of New Democracy at Thissio. Since 1997 he has been a member of the Central Committee of New Democracy. In the elections of 2004 he was a candidate for the European Parliament with the political party of New Democracy and from September, 2007 till the elections for the European Parliament in 2009 he remained a Member of the European Parliament. From November,2009 until July 2011 he was Secretary of the Organizing Sector of New Democracy and from July, 2011 until May,2012 he was Deputy Secretary of Health Sector of the party.
In August, 2012 he became General Secretary of the Decentralized Administration of Peloponnese, West Greece and Ionion. Since February,2014 he serves as the General Secretary of the Decentralized Administration of Attica.